Synthesis of the New Ring System Bispyrido[4',3':4,5]pyrrolo\ud [1,2-a:1',2'-d]pyrazine and Its Deaza Analogue

摘要

Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d]\udpyrazine-6,13-dione and its deaza analogue pyrido[4'',3'':4',5']pyrrolo-[1',2':4,5]pyrazino\ud[1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence.\udSymmetrical derivatives of the former ring system were obtained through self\udcondensation. On the other hand, condensation of 6-azaindole carboxylic acid with indole\ud2-carboxylic acid afforded the deaza analogue ring system. Derivatives of the title ring\udsystem were tested by the National Cancer Institute (Bethesda, MD, USA) and four of\udthem exhibited modest activity against MCF7 (a breast cancer cell line) and/or UO-31\ud(a renal cancer cell line).